In addition to the computational predicted interactions produced in our Lab, Predictome database also collects experimentally determined ones by either directly importing from literatures, or by synchronizing with existing interaction databases such as Biogrid, MINT,  BIND, MIPS, IntAct, HPRD etc. The integration of the interaction is gene-based, meaning that two protein nodes will be recognized as a single protein, if the same gene encodes them. This decision not to distinguish gene nodes from protein nodes was based primarily on the following observations:
Because genes often encode multiple proteins, using gene id to represent both gene and protein is a natural choice; otherwise, uncertainty may arise when integrating interaction data. For example, for a gene with two splice variants, the variant to use when integrating interactions between the MINT (protein-based) and Biogrid databases (gene-based) will be ambiguous. The shortcoming of this solution is that certain splice variants may only share a subset of interactions. This dilemma can be overcome if alternative splicing knowledge is represented using a metanode, an undergoing process of this project.


Summary
Total*:778490 Computational predicted:300297 Experimental determined:478193
Species Supported:110
Aeropyrum pernix:3353 Agrobacterium tumefaciens strain C58 (Cereon):11802
Akodon aerosus:83 Aquifex aeolicus:2815
Arabidopsis thaliana:6943 Archaeoglobus fulgidus:4324
Artocarpus heterophyllus:2 Azotobacter vinelandii:8
Bacillus halodurans:6059 Bacillus subtilis:7542
Borrelia burgdorferi:1866 Bos taurus:380
Brucella melitensis:4482 Buchnera sp. APS:1529
Caenorhabditis elegans:13642 Campylobacter jejuni:3114
Candida albicans:5 Canis lupus familiaris:7
Caulobacter crescentus:5904 Chlamydia pneumoniae:1589
Chlamydia trachomatis:1537 Chlamydomonas reinhardtii:30
Clostridium acetobutylicum:3404 Corynebacterium glutamicum:2428
Danio rerio:17 Deinococcus radiodurans:3953
Desulfovibrio desulfuricans:4 Drosophila melanogaster:30591
Encephalitozoon_cuniculi:3788 Enterobacteria phage:44
Enterobacteria phage PRD1:1 Escherichia coli K-12:11545
Escherichia coli O157:8029 Escherichia coli O157:H7:7480
Fusobacterium nucleatum:1940 Gallus gallus:163
Geobacillus stearothermophilus:14 Haemophilus influenzae:3193
Haloarcula marismortui:5 Halobacterium sp. NRC-1:4582
Helicobacter pylori 26695:4399 Helicobacter pylori J99:2585
Hepatitis C virus:4 Homo sapiens:131654
Human herpesvirus 3:37 Human herpesvirus 8:46
Human immunodeficiency virus:52 Human immunodeficiency virus 1:23
Human papillomavirus type 16:3 Influenza A virus:14
Klebsiella pneumoniae:9 Lactococcus lactis:2668
Listeria innocua:3819 Mesorhizobium loti:15959
Methanocaldococcus jannaschii:3253 Methanopyrus kandleri AV19:2696
Methanosarcina acetivorans str.C2A:3444 Methanothermobacter thermautotrophicus:3725
Mus musculus:8579 Mycobacterium leprae:1859
Mycobacterium tuberculosis:7799 Mycobacterium tuberculosis CDC1551:2856
Mycoplasma genitalium:1011 Mycoplasma pneumoniae:939
Mycoplasma pulmonis:979 Neisseria meningitidis MC58:2938
Neisseria meningitidis Z2491:2614 Nostoc sp. PCC 7120:4509
Oryctolagus cuniculus:26 Oryza sativa:349
Pan troglodytes:1 Paracoccus denitrificans:6
Pasteurella multocida:3390 Pisum sativum:3
Plasmodium falciparum:1706 Pseudomonas aeruginosa:18843
Pseudomonas putida:14 Pyrobaculum aerophilum:3015
Pyrococcus abyssi:3436 Pyrococcus furiosus:6
Pyrococcus horikoshii:3295 Ralstonia solanacearum:7476
Rattus norvegicus:3194 Rhodobacter sphaeroides:1
Rickettsia conorii:1662 Rickettsia prowazekii:1711
Rickettsia sibirica 246:116 Saccharomyces cerevisiae:270672
Salmonella typhimurium LT2:5645 Schizosaccharomyces pombe:23151
Sinorhizobium meliloti:13454 Staphylococcus aureus:9
Staphylococcus aureus N315:2697 Streptococcus pneumoniae TIGR4:2317
Streptococcus pyogenes:2232 Sulfolobus solfataricus:3050
Sus scrofa:31 Synechocystis:7742
synthetic construct:23 Thermoplasma acidophilum:2901
Thermoplasma volcanium:2959 Thermotoga maritima:3309
Thermus aquaticus:3 Thermus thermophilus:68
Treponema pallidum:1956 Ureaplasma urealyticum:1030
Vibrio cholerae:10770 Xenopus laevis:235
Xylella fastidiosa:3733 Yersinia pestis:5603
Aeropyrum pernix
domain fusion(M0036):126 gene neighbourhoods(M0038):271
phylogenetic profile(M0037):2956
Agrobacterium tumefaciens strain C58 (Cereon)
phylogenetic profile(M0037):11802
Akodon aerosus
affinity technology(M0045):13 two hybrid test(M0034):70
Aquifex aeolicus
domain fusion(M0036):282 gene neighbourhoods(M0038):206
phylogenetic profile(M0037):2327 structure based prediction(M0048):1
Arabidopsis thaliana
affinity technology(M0045):569 anti bait coimmunoprecipitation(M0089):136
anti tag coimmunoprecipitation(M0065):314 Biochemical Activity(M0083):118
blue native page(M0096):33 Chromatin Immunoprecipitation (ChIP)(M0042):1
chromatography technology(M0085):25 Co-fractionation(M0079):66
coimmunoprecipitation(M0010):81 confocal microscopy(M0094):64
copurification(M0013):15 cosedimentation(M0033):6
cross-linking studies(M0014):6 Dosage Growth Defect(M0082):3
Dosage Rescue(M0077):1 electron microscopy(M0062):10
electrophoretic mobility shift assay(M0098):9 elisa:enzyme-linked immunosorbent assay(M0051):1
enzymatic study(M0066):47 far western blotting(M0060):43
filter binding(M0053):15 fluorescence technology(M0052):164
Gel retardation assays (M0019):2 genetic,synthetic growth effect(M0055):8
isothermal titration calorimetry(M0103):4 molecular sieving(M0018):49
nuclear magnetic resonance(M0070):2 Other Biophysical(M0031):83
phage display(M0050):98 Phenotypic Enhancement(M0075):45
Phenotypic Suppression(M0080):51 phosphatase assay(M0101):3
protein array(M0068):570 protein complementation assay(M0069):31
protein kinase assay(M0095):63 Protein-RNA(M0078):3
pull down(M0067):386 Reconstituted Complex(M0074):616
resonance energy transfer(M0061):35 structure based prediction(M0048):22
surface plasmon resonance(M0049):6 Synthetic Rescue(M0081):2
tandem affinity purification(M0088):200 two hybrid test(M0034):2882
ubiquitin reconstruction(M0100):61
Archaeoglobus fulgidus
domain fusion(M0036):798 gene neighbourhoods(M0038):462
phylogenetic profile(M0037):3056 structure based prediction(M0048):9
Artocarpus heterophyllus
structure based prediction(M0048):2
Azotobacter vinelandii
resonance energy transfer(M0061):1 structure based prediction(M0048):7
Bacillus halodurans
gene neighbourhoods(M0038):833 phylogenetic profile(M0037):5225
structure based prediction(M0048):1
Bacillus subtilis
domain fusion(M0036):2213 gene neighbourhoods(M0038):812
phylogenetic profile(M0037):4489 structure based prediction(M0048):29
Borrelia burgdorferi
domain fusion(M0036):41 gene neighbourhoods(M0038):203
phylogenetic profile(M0037):1620 structure based prediction(M0048):2
Bos taurus
affinity technology(M0045):5 anti bait coimmunoprecipitation(M0089):118
Chromatin Immunoprecipitation (ChIP)(M0042):1 chromatography technology(M0085):61
Co-fractionation(M0079):1 coimmunoprecipitation(M0010):9
confocal microscopy(M0094):1 copurification(M0013):1
cosedimentation(M0033):17 enzymatic study(M0066):3
filter binding(M0053):1 inferred by curator(M0093):1
Other Biophysical(M0031):13 pull down(M0067):21
Reconstituted Complex(M0074):1 structure based prediction(M0048):116
surface plasmon resonance(M0049):2 two hybrid test(M0034):5
x-ray crystallography(M0071):5
Brucella melitensis
phylogenetic profile(M0037):4482
Buchnera sp. APS
gene neighbourhoods(M0038):241 phylogenetic profile(M0037):1288
Caenorhabditis elegans
affinity technology(M0045):354 anti bait coimmunoprecipitation(M0089):72
anti tag coimmunoprecipitation(M0065):165 Biochemical Activity(M0083):1
chromatography technology(M0085):4 coimmunoprecipitation(M0010):89
colocalization by immunostaining(M0025):1 colocalization/visualisation technologies(M0063):2
Competition binding(M0012):3 confocal microscopy(M0094):3
enzymatic study(M0066):3 far western blotting(M0060):4
fluorescence technology(M0052):31 Gel retardation assays (M0019):4
imaging techniques(M0072):2 molecular sieving(M0018):16
Other Biophysical(M0031):33 Phenotypic Enhancement(M0075):2079
protein complementation assay(M0069):3 protein kinase assay(M0095):5
pull down(M0067):105 Reconstituted Complex(M0074):1
structure based prediction(M0048):6 surface plasmon resonance(M0049):2
two hybrid test(M0034):10653 x-ray crystallography(M0071):3
Campylobacter jejuni
domain fusion(M0036):230 gene neighbourhoods(M0038):322
phylogenetic profile(M0037):2558 structure based prediction(M0048):4
Candida albicans
molecular sieving(M0018):1 structure based prediction(M0048):1
two hybrid test(M0034):3
Canis lupus familiaris
affinity technology(M0045):2 coimmunoprecipitation(M0010):1
pull down(M0067):2 structure based prediction(M0048):2
two hybrid test(M0034):1
Caulobacter crescentus
gene neighbourhoods(M0038):565 phylogenetic profile(M0037):5339
Chlamydia pneumoniae
domain fusion(M0036):103 gene neighbourhoods(M0038):171
phylogenetic profile(M0037):1315
Chlamydia trachomatis
domain fusion(M0036):57 gene neighbourhoods(M0038):167
phylogenetic profile(M0037):1313
Chlamydomonas reinhardtii
anti bait coimmunoprecipitation(M0089):18 Biochemical Activity(M0083):5
far western blotting(M0060):1 structure based prediction(M0048):6
Clostridium acetobutylicum
phylogenetic profile(M0037):3403 structure based prediction(M0048):1
Corynebacterium glutamicum
phylogenetic profile(M0037):2427 structure based prediction(M0048):1
Danio rerio
affinity technology(M0045):3 coimmunoprecipitation(M0010):1
fluorescence technology(M0052):1 Gel retardation assays (M0019):1
Other Biophysical(M0031):1 solid phase assay(M0102):7
structure based prediction(M0048):1 surface plasmon resonance(M0049):4
Deinococcus radiodurans
domain fusion(M0036):1204 gene neighbourhoods(M0038):415
phylogenetic profile(M0037):2331 structure based prediction(M0048):3
Desulfovibrio desulfuricans
structure based prediction(M0048):4
Drosophila melanogaster
affinity technology(M0045):303 anti bait coimmunoprecipitation(M0089):92
anti tag coimmunoprecipitation(M0065):85 Biochemical Activity(M0083):19
chromatography technology(M0085):14 Co-fractionation(M0079):39
coimmunoprecipitation(M0010):134 colocalization by immunostaining(M0025):2
colocalization/visualisation technologies(M0063):14 Competition binding(M0012):11
confocal microscopy(M0094):7 copurification(M0013):35
cosedimentation(M0033):18 cross-linking studies(M0014):10
Dosage Rescue(M0077):1 electron microscopy(M0062):5
electrophoretic mobility shift assay(M0098):2 elisa:enzyme-linked immunosorbent assay(M0051):3
enzymatic study(M0066):4 far western blotting(M0060):15
filter binding(M0053):2 fluorescence technology(M0052):8
Gel retardation assays (M0019):8 imaging techniques(M0072):13
inferred by curator(M0093):5 isothermal titration calorimetry(M0103):1
molecular sieving(M0018):20 Other Biophysical(M0031):932
phage display(M0050):14 Phenotypic Enhancement(M0075):1408
Phenotypic Suppression(M0080):1798 phosphatase assay(M0101):2
protein complementation assay(M0069):3 protein kinase assay(M0095):5
Protein-RNA(M0078):1 pull down(M0067):159
Reconstituted Complex(M0074):146 structure based prediction(M0048):25
surface plasmon resonance(M0049):5 tandem affinity purification(M0088):16
two hybrid test(M0034):25208 western blot(M0021):1
x-ray crystallography(M0071):6
Encephalitozoon_cuniculi
phylogenetic profile(M0037):3788
Enterobacteria phage
cross-linking studies(M0014):1 molecular sieving(M0018):1
structure based prediction(M0048):4 two hybrid test(M0034):38
x-ray crystallography(M0071):1
Enterobacteria phage PRD1
structure based prediction(M0048):1
Escherichia coli K-12
affinity technology(M0045):12 anti tag coimmunoprecipitation(M0065):1772
coimmunoprecipitation(M0010):7 colocalization by immunostaining(M0025):1
cosedimentation(M0033):1 cross-linking studies(M0014):4
domain fusion(M0036):2697 elisa:enzyme-linked immunosorbent assay(M0051):2
far western blotting(M0060):6 Gel retardation assays (M0019):28
gene neighbourhoods(M0038):1019 molecular sieving(M0018):3
Other Biophysical(M0031):25 phylogenetic profile(M0037):5127
pull down(M0067):2 structure based prediction(M0048):794
surface plasmon resonance(M0049):2 two hybrid test(M0034):44
Escherichia coli O157
gene neighbourhoods(M0038):1295 phylogenetic profile(M0037):6734
Escherichia coli O157:H7
anti tag coimmunoprecipitation(M0065):596 copurification(M0013):1
elisa:enzyme-linked immunosorbent assay(M0051):1 phylogenetic profile(M0037):6881
two hybrid test(M0034):1
Fusobacterium nucleatum
phylogenetic profile(M0037):1940
Gallus gallus
affinity technology(M0045):15 anti bait coimmunoprecipitation(M0089):2
anti tag coimmunoprecipitation(M0065):18 Biochemical Activity(M0083):1
Co-fractionation(M0079):3 coimmunoprecipitation(M0010):14
colocalization by immunostaining(M0025):2 cosedimentation(M0033):2
cross-linking studies(M0014):6 elisa:enzyme-linked immunosorbent assay(M0051):1
far western blotting(M0060):2 fluorescence technology(M0052):6
Gel retardation assays (M0019):3 genetic,synthetic lethal(M0047):1
Other Biophysical(M0031):6 phage display(M0050):2
pull down(M0067):12 Reconstituted Complex(M0074):4
structure based prediction(M0048):55 surface plasmon resonance(M0049):1
transient coexpression(M0039):1 two hybrid test(M0034):2
x-ray crystallography(M0071):6
Geobacillus stearothermophilus
Other Biophysical(M0031):2 structure based prediction(M0048):13
Haemophilus influenzae
domain fusion(M0036):194 gene neighbourhoods(M0038):527
phylogenetic profile(M0037):2424 structure based prediction(M0048):48
Haloarcula marismortui
structure based prediction(M0048):5
Halobacterium sp. NRC-1
gene neighbourhoods(M0038):327 phylogenetic profile(M0037):4255
Helicobacter pylori 26695
domain fusion(M0036):202 gene neighbourhoods(M0038):233
Other Biophysical(M0031):1433 phylogenetic profile(M0037):2267
structure based prediction(M0048):1 two hybrid test(M0034):264
Helicobacter pylori J99
blue native page(M0096):25 domain fusion(M0036):132
gene neighbourhoods(M0038):235 phylogenetic profile(M0037):2193
Hepatitis C virus
affinity technology(M0045):1 coimmunoprecipitation(M0010):1
colocalization by immunostaining(M0025):1 colocalization/visualisation technologies(M0063):1
cross-linking studies(M0014):1 far western blotting(M0060):1
structure based prediction(M0048):1 two hybrid test(M0034):1
Homo sapiens
affinity technology(M0045):17281 anti bait coimmunoprecipitation(M0089):7545
anti tag coimmunoprecipitation(M0065):7078 Biochemical Activity(M0083):1127
blue native page(M0096):69 Chromatin Immunoprecipitation (ChIP)(M0042):79
chromatography technology(M0085):285 Co-fractionation(M0079):304
coimmunoprecipitation(M0010):3885 colocalization by immunostaining(M0025):228
colocalization/visualisation technologies(M0063):352 comigration in non denaturing gel electrophoresis(M0097):26
Competition binding(M0012):95 confocal microscopy(M0094):174
copurification(M0013):853 cosedimentation(M0033):150
cross-linking studies(M0014):2668 dihydrofolate reductase reconstruction(M0090):6
electron microscopy(M0062):6 electrophoretic mobility shift assay(M0098):8
elisa:enzyme-linked immunosorbent assay(M0051):125 enzymatic study(M0066):241
far western blotting(M0060):433 filter binding(M0053):190
fluorescence technology(M0052):387 Gel retardation assays (M0019):28
imaging techniques(M0072):55 inferred by curator(M0093):135
Invitro(M0084):19310 Invivo(M0073):17932
isothermal titration calorimetry(M0103):17 mass spectrometry studies of complexes(M0028):4
molecular sieving(M0018):207 nuclear magnetic resonance(M0070):40
Other Biophysical(M0031):995 other genetic(M0030):12
peptide array(M0092):975 phage display(M0050):107
Phenotypic Enhancement(M0075):130 Phenotypic Suppression(M0080):118
phosphatase assay(M0101):191 protein array(M0068):389
protein complementation assay(M0069):59 protein kinase assay(M0095):143
Protein-RNA(M0078):8 pull down(M0067):3643
Reconstituted Complex(M0074):8189 resonance energy transfer(M0061):49
solid phase assay(M0102):8 structure based prediction(M0048):666
surface plasmon resonance(M0049):175 Synthetic Rescue(M0081):2
tandem affinity purification(M0088):2413 TFSVM (Predicted TF by SVM)(M0064):11250
transient coexpression(M0039):1 two hybrid test(M0034):20571
ubiquitin reconstruction(M0100):6 western blot(M0021):1
x-ray crystallography(M0071):242
Human herpesvirus 3
structure based prediction(M0048):1 two hybrid test(M0034):37
Human herpesvirus 8
anti tag coimmunoprecipitation(M0065):19 Other Biophysical(M0031):1
two hybrid test(M0034):26
Human immunodeficiency virus
affinity technology(M0045):2 coimmunoprecipitation(M0010):1
cosedimentation(M0033):1 cross-linking studies(M0014):2
Other Biophysical(M0031):2 resonance energy transfer(M0061):1
structure based prediction(M0048):45 two hybrid test(M0034):1
Human immunodeficiency virus 1
affinity technology(M0045):3 coimmunoprecipitation(M0010):2
cosedimentation(M0033):1 cross-linking studies(M0014):2
Other Biophysical(M0031):1 resonance energy transfer(M0061):1
structure based prediction(M0048):14 two hybrid test(M0034):1
Human papillomavirus type 16
coimmunoprecipitation(M0010):1 pull down(M0067):1
two hybrid test(M0034):2
Influenza A virus
structure based prediction(M0048):14
Klebsiella pneumoniae
structure based prediction(M0048):9
Lactococcus lactis
gene neighbourhoods(M0038):412 Other Biophysical(M0031):2
phylogenetic profile(M0037):2253 structure based prediction(M0048):2
Listeria innocua
phylogenetic profile(M0037):3818 structure based prediction(M0048):1
Mesorhizobium loti
gene neighbourhoods(M0038):1185 phylogenetic profile(M0037):14773
structure based prediction(M0048):1
Methanocaldococcus jannaschii
domain fusion(M0036):299 gene neighbourhoods(M0038):205
phylogenetic profile(M0037):2738 structure based prediction(M0048):11
Methanopyrus kandleri AV19
phylogenetic profile(M0037):2696
Methanosarcina acetivorans str.C2A
phylogenetic profile(M0037):3444
Methanothermobacter thermautotrophicus
blue native page(M0096):39 domain fusion(M0036):591
Gel retardation assays (M0019):1 gene neighbourhoods(M0038):347
phylogenetic profile(M0037):2728 structure based prediction(M0048):16
surface plasmon resonance(M0049):1 two hybrid test(M0034):2
x-ray crystallography(M0071):1
Mus musculus
affinity technology(M0045):811 anti bait coimmunoprecipitation(M0089):642
anti tag coimmunoprecipitation(M0065):699 Biochemical Activity(M0083):8
blue native page(M0096):71 Chromatin Immunoprecipitation (ChIP)(M0042):27
chromatography technology(M0085):351 Co-fractionation(M0079):17
coimmunoprecipitation(M0010):1135 colocalization by immunostaining(M0025):37
colocalization/visualisation technologies(M0063):22 Competition binding(M0012):44
confocal microscopy(M0094):48 copurification(M0013):53
cosedimentation(M0033):743 cross-linking studies(M0014):353
electron microscopy(M0062):5 electrophoretic mobility shift assay(M0098):5
elisa:enzyme-linked immunosorbent assay(M0051):23 enzymatic study(M0066):18
far western blotting(M0060):58 filter binding(M0053):11
fluorescence technology(M0052):63 Gel retardation assays (M0019):17
genetic,synthetic lethal(M0047):1 imaging techniques(M0072):9
inferred by curator(M0093):59 isothermal titration calorimetry(M0103):2
mass spectrometry studies of complexes(M0028):1 molecular sieving(M0018):26
nuclear magnetic resonance(M0070):3 Other Biophysical(M0031):546
other genetic(M0030):4 phage display(M0050):16
Phenotypic Enhancement(M0075):4 Phenotypic Suppression(M0080):6
protein array(M0068):1 protein complementation assay(M0069):1
protein kinase assay(M0095):3 pull down(M0067):539
Reconstituted Complex(M0074):112 resonance energy transfer(M0061):4
structure based prediction(M0048):333 surface plasmon resonance(M0049):23
tandem affinity purification(M0088):44 transient coexpression(M0039):1
two hybrid test(M0034):1563 x-ray crystallography(M0071):23
Mycobacterium leprae
gene neighbourhoods(M0038):220 phylogenetic profile(M0037):1638
structure based prediction(M0048):1
Mycobacterium tuberculosis
affinity technology(M0045):4 domain fusion(M0036):4292
gene neighbourhoods(M0038):574 Other Biophysical(M0031):4
phylogenetic profile(M0037):2863 structure based prediction(M0048):56
two hybrid test(M0034):7
Mycobacterium tuberculosis CDC1551
phylogenetic profile(M0037):2855 structure based prediction(M0048):1
Mycoplasma genitalium
domain fusion(M0036):24 gene neighbourhoods(M0038):131
phylogenetic profile(M0037):856
Mycoplasma pneumoniae
gene neighbourhoods(M0038):147 phylogenetic profile(M0037):791
structure based prediction(M0048):1
Mycoplasma pulmonis
phylogenetic profile(M0037):979
Neisseria meningitidis MC58
domain fusion(M0036):222 gene neighbourhoods(M0038):339
phylogenetic profile(M0037):2377 structure based prediction(M0048):1
Neisseria meningitidis Z2491
gene neighbourhoods(M0038):345 phylogenetic profile(M0037):2269
Nostoc sp. PCC 7120
phylogenetic profile(M0037):4508 structure based prediction(M0048):1
Oryctolagus cuniculus
coimmunoprecipitation(M0010):3 copurification(M0013):1
cross-linking studies(M0014):1 filter binding(M0053):1
Gel retardation assays (M0019):1 molecular sieving(M0018):1
Other Biophysical(M0031):1 phage display(M0050):1
pull down(M0067):1 resonance energy transfer(M0061):1
structure based prediction(M0048):14 two hybrid test(M0034):1
x-ray crystallography(M0071):1
Oryza sativa
affinity technology(M0045):3 anti bait coimmunoprecipitation(M0089):3
anti tag coimmunoprecipitation(M0065):2 coimmunoprecipitation(M0010):2
molecular sieving(M0018):2 structure based prediction(M0048):1
two hybrid test(M0034):336
Pan troglodytes
structure based prediction(M0048):1
Paracoccus denitrificans
structure based prediction(M0048):6
Pasteurella multocida
gene neighbourhoods(M0038):690 phylogenetic profile(M0037):2700
Pisum sativum
cross-linking studies(M0014):1 structure based prediction(M0048):2
Plasmodium falciparum
enzymatic study(M0066):4 molecular sieving(M0018):1
structure based prediction(M0048):4 two hybrid test(M0034):1698
Pseudomonas aeruginosa
cross-linking studies(M0014):1 domain fusion(M0036):6577
gene neighbourhoods(M0038):1382 Other Biophysical(M0031):3
phylogenetic profile(M0037):10828 structure based prediction(M0048):52
Pseudomonas putida
structure based prediction(M0048):13 x-ray crystallography(M0071):1
Pyrobaculum aerophilum
phylogenetic profile(M0037):3015
Pyrococcus abyssi
domain fusion(M0036):224 gene neighbourhoods(M0038):387
phylogenetic profile(M0037):2824 structure based prediction(M0048):1
Pyrococcus furiosus
coimmunoprecipitation(M0010):1 structure based prediction(M0048):5
Pyrococcus horikoshii
domain fusion(M0036):231 gene neighbourhoods(M0038):307
phylogenetic profile(M0037):2749 structure based prediction(M0048):8
Ralstonia solanacearum
phylogenetic profile(M0037):7476
Rattus norvegicus
affinity technology(M0045):339 anti bait coimmunoprecipitation(M0089):148
anti tag coimmunoprecipitation(M0065):718 Biochemical Activity(M0083):4
blue native page(M0096):6 Co-fractionation(M0079):9
coimmunoprecipitation(M0010):633 colocalization by immunostaining(M0025):19
colocalization/visualisation technologies(M0063):15 Competition binding(M0012):20
confocal microscopy(M0094):21 copurification(M0013):27
cosedimentation(M0033):13 cross-linking studies(M0014):13
electron microscopy(M0062):1 elisa:enzyme-linked immunosorbent assay(M0051):2
enzymatic study(M0066):7 far western blotting(M0060):40
filter binding(M0053):18 fluorescence technology(M0052):20
Gel retardation assays (M0019):3 imaging techniques(M0072):5
inferred by curator(M0093):28 isothermal titration calorimetry(M0103):1
molecular sieving(M0018):4 Other Biophysical(M0031):136
other genetic(M0030):1 phage display(M0050):4
protein array(M0068):2 protein kinase assay(M0095):1
pull down(M0067):363 Reconstituted Complex(M0074):62
resonance energy transfer(M0061):7 solid phase assay(M0102):1
structure based prediction(M0048):100 surface plasmon resonance(M0049):10
two hybrid test(M0034):377 x-ray crystallography(M0071):22
Rhodobacter sphaeroides
structure based prediction(M0048):1
Rickettsia conorii
Other Biophysical(M0031):1 phylogenetic profile(M0037):1661
Rickettsia prowazekii
domain fusion(M0036):48 gene neighbourhoods(M0038):165
phylogenetic profile(M0037):1498
Rickettsia sibirica 246
two hybrid test(M0034):116
Saccharomyces cerevisiae
Affinity Column(M0006):33 Affinity Precipitation(M0044):63
affinity technology(M0045):36040 anti bait coimmunoprecipitation(M0089):248
anti tag coimmunoprecipitation(M0065):7982 Bayesian Predicted Interaction(M0046):15918
Biochemical Activity(M0083):5578 blue native page(M0096):25
Chromatin Immunoprecipitation (ChIP)(M0042):4364 chromatography technology(M0085):605
Co-fractionation(M0079):618 coimmunoprecipitation(M0010):857
colocalization by immunostaining(M0025):6 colocalization/visualisation technologies(M0063):392
comigration in non denaturing gel electrophoresis(M0097):23 Competition binding(M0012):9
confocal microscopy(M0094):15 copurification(M0013):1400
cosedimentation(M0033):177 cross-linking studies(M0014):88
dihydrofolate reductase reconstruction(M0090):9389 domain fusion(M0036):3017
Dosage Growth Defect(M0082):163 Dosage Lethality(M0076):621
Dosage Rescue(M0077):3461 electron microscopy(M0062):61
electrophoretic mobility shift assay(M0098):1 elisa:enzyme-linked immunosorbent assay(M0051):15
enzymatic study(M0066):28 far western blotting(M0060):86
filter binding(M0053):8 fluorescence technology(M0052):140
Gel retardation assays (M0019):34 gene neighbourhoods(M0038):9
genetic,conditional synthetic lethal(M0054):15 genetic suppression(M0058):210
genetic,suppression expression alteration(M0057):145 genetic,suppression mutation(M0056):39
genetic,synthetic growth effect(M0055):14892 genetic,synthetic lethal(M0047):12461
genetic synthetic phenotype(M0059):46 genetic,tetrad analysis(M0020):1318
inferred by author(M0091):4263 inferred by curator(M0093):633
In vitro binding(M0026):26 mass spectrometry studies of complexes(M0028):1
molecular sieving(M0018):167 Negative Genetic(M0104):68613
nuclear magnetic resonance(M0070):3 Other Biophysical(M0031):6706
other genetic(M0030):143 peptide array(M0092):180
phage display(M0050):16 Phenotypic Enhancement(M0075):3075
Phenotypic Suppression(M0080):1768 phosphatase assay(M0101):2
phylogenetic profile(M0037):8302 Positive Genetic(M0105):12801
protein array(M0068):529 protein complementation assay(M0069):15
protein kinase assay(M0095):16 Protein-RNA(M0078):518
pull down(M0067):1379 Reconstituted Complex(M0074):2217
resonance energy transfer(M0061):3 structure based prediction(M0048):375
surface plasmon resonance(M0049):46 Synthetic Haploinsufficiency(M0086):201
Synthetic Rescue(M0081):3094 tandem affinity purification(M0088):19673
Transcription Factor(M0041):238 transient coexpression(M0039):98
two hybrid test(M0034):14836 ubiquitin reconstruction(M0100):98
x-ray crystallography(M0071):53
Salmonella typhimurium LT2
coimmunoprecipitation(M0010):2 cross-linking studies(M0014):1
phylogenetic profile(M0037):5625 structure based prediction(M0048):15
two hybrid test(M0034):2
Schizosaccharomyces pombe
affinity technology(M0045):1726 anti bait coimmunoprecipitation(M0089):75
anti tag coimmunoprecipitation(M0065):210 Biochemical Activity(M0083):116
chromatography technology(M0085):38 Co-fractionation(M0079):38
coimmunoprecipitation(M0010):50 colocalization/visualisation technologies(M0063):220
confocal microscopy(M0094):2 copurification(M0013):99
cosedimentation(M0033):29 cross-linking studies(M0014):5
Dosage Growth Defect(M0082):25 Dosage Lethality(M0076):64
Dosage Rescue(M0077):441 enzymatic study(M0066):8
far western blotting(M0060):27 fluorescence technology(M0052):52
genetic,synthetic growth effect(M0055):1143 genetic,synthetic lethal(M0047):477
inferred by curator(M0093):29 isothermal titration calorimetry(M0103):1
molecular sieving(M0018):12 Negative Genetic(M0104):5769
Other Biophysical(M0031):10 Phenotypic Enhancement(M0075):618
Phenotypic Suppression(M0080):391 phylogenetic profile(M0037):8122
Positive Genetic(M0105):1811 protein complementation assay(M0069):3
protein kinase assay(M0095):7 Protein-RNA(M0078):1
pull down(M0067):125 Reconstituted Complex(M0074):232
structure based prediction(M0048):13 surface plasmon resonance(M0049):2
Synthetic Rescue(M0081):331 tandem affinity purification(M0088):254
two hybrid test(M0034):580 x-ray crystallography(M0071):1
Sinorhizobium meliloti
phylogenetic profile(M0037):13453 structure based prediction(M0048):1
Staphylococcus aureus
Other Biophysical(M0031):1 structure based prediction(M0048):8
Staphylococcus aureus N315
phylogenetic profile(M0037):2697
Streptococcus pneumoniae TIGR4
phylogenetic profile(M0037):2316 structure based prediction(M0048):1
Streptococcus pyogenes
gene neighbourhoods(M0038):354 phylogenetic profile(M0037):1871
structure based prediction(M0048):7
Sulfolobus solfataricus
phylogenetic profile(M0037):3043 structure based prediction(M0048):7
Sus scrofa
coimmunoprecipitation(M0010):2 cross-linking studies(M0014):1
pull down(M0067):1 structure based prediction(M0048):27
Synechocystis
anti bait coimmunoprecipitation(M0089):7 Biochemical Activity(M0083):16
blue native page(M0096):4 chromatography technology(M0085):35
comigration in non denaturing gel electrophoresis(M0097):39 cross-linking studies(M0014):2
domain fusion(M0036):4563 electron microscopy(M0062):4
enzymatic study(M0066):1 far western blotting(M0060):1
fluorescence technology(M0052):3 gene neighbourhoods(M0038):273
molecular sieving(M0018):2 nuclear magnetic resonance(M0070):1
Other Biophysical(M0031):2 phylogenetic profile(M0037):2667
protein complementation assay(M0069):4 protein kinase assay(M0095):2
pull down(M0067):93 resonance energy transfer(M0061):1
structure based prediction(M0048):2 two hybrid test(M0034):24
x-ray crystallography(M0071):2
synthetic construct
structure based prediction(M0048):23
Thermoplasma acidophilum
gene neighbourhoods(M0038):216 phylogenetic profile(M0037):2680
structure based prediction(M0048):5
Thermoplasma volcanium
gene neighbourhoods(M0038):290 phylogenetic profile(M0037):2669
Thermotoga maritima
domain fusion(M0036):529 gene neighbourhoods(M0038):473
phylogenetic profile(M0037):2256 structure based prediction(M0048):51
Thermus aquaticus
structure based prediction(M0048):3
Thermus thermophilus
structure based prediction(M0048):68
Treponema pallidum
domain fusion(M0036):54 gene neighbourhoods(M0038):203
phylogenetic profile(M0037):1698 structure based prediction(M0048):1
Ureaplasma urealyticum
domain fusion(M0036):32 gene neighbourhoods(M0038):141
phylogenetic profile(M0037):857
Vibrio cholerae
domain fusion(M0036):4551 gene neighbourhoods(M0038):1075
phylogenetic profile(M0037):5131 structure based prediction(M0048):14
Xenopus laevis
affinity technology(M0045):28 anti bait coimmunoprecipitation(M0089):33
anti tag coimmunoprecipitation(M0065):12 chromatography technology(M0085):6
coimmunoprecipitation(M0010):38 colocalization/visualisation technologies(M0063):1
Competition binding(M0012):2 cosedimentation(M0033):8
cross-linking studies(M0014):13 electron microscopy(M0062):2
enzymatic study(M0066):2 far western blotting(M0060):2
fluorescence technology(M0052):1 Gel retardation assays (M0019):1
inferred by curator(M0093):6 molecular sieving(M0018):2
Other Biophysical(M0031):7 protein complementation assay(M0069):2
pull down(M0067):28 Reconstituted Complex(M0074):10
structure based prediction(M0048):17 two hybrid test(M0034):14
x-ray crystallography(M0071):3
Xylella fastidiosa
domain fusion(M0036):357 gene neighbourhoods(M0038):528
phylogenetic profile(M0037):2848
Yersinia pestis
phylogenetic profile(M0037):5602 structure based prediction(M0048):1


*This total number excludes the number of interactions extracts from the KEGG pathways; otherwise, the number shall >1M.